Shimamura, T., et al. – Combination IL-4 cytotoxin with gemcitabine may be effective therapy for treatment of pancreatic ductal adenocarcinoma (PDA).Methods
Metastatic and orthotopic mouse model using green fluorescent protein–transfected cancer cells and whole-body imaging system to confirm synergistic antitumor activity in vivo and monitor real-time disease progression
Results
Moderate- to high-density surface IL-4 receptor (IL-4R) was seen in 60% of tumor samples from PDA pts versus no or low-density IL-4R in normal pancreatic samples
IL-4 cytotoxin was specifically and highly cytotoxic to 6 of 8 pancreatic cancer cell lines
Combination IL-4 cytotoxin with gemcitabine had synergistic antitumor activity in vitro
Combined agents completely eradicated tumors in 40% of nude mice with small established PDA tumors
Combined treatment significantly prolonged survival of nude mice with advanced distant metastatic PDA tumors on day 14
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