Halliday, B. P., et al. – In pts who underwent surgical resection for esophageal carcinoma and esophagogastric junction carcinoma types I and II, neoadjuvant chemotherapy (NAC) was associated with a significant reduction in the postoperative inpatient mortality rate. Methods
Prospective study of resections for esophageal/junctional (types I and II) adenocarcinoma or squamous cell carcinoma
Comparison of data from 167 pts with T3 and/or N1 disease who either underwent NAC (89 pts) or not (non-NAC, 78 pts)
Results
In-hospital postoperative mortality rate of the NAC group was significantly lower than for the non-NAC group
Most deaths caused by cardiorespiratory complications; no significant difference in between the two groups rates of chest infections, anastomotic leaks, wound infections, reoperations, readmission to ITU, or overall complications
Both 2-year survival rate and long-term survival were greater for NAC pts; differences were not statistically significant
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