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Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade
Journal of Neuro-Oncology, 09/26/07

Buckner, J., et al. - In a trial to assess whether oligodendroglial elements are associated with better outcomes, it was found that patients with anaplastic oligoastrocytoma have distinct outcomes based upon grade (OA3 vs. OA4) and in comparison with pure astrocytoma (AA or GBM)

Methods

Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-grade gliomas
All pathology slides were reviewed by one of the authors
Patients were grouped by cell type and grade, survival distributions were compared by log-rank statistic, and multiple analyses were done

Results

Of 1368 patients, 68 had AOA, including 21 Grade 3 (OA3) and 47 grade 4 (OA4), 153 had anaplastic astrocytoma (AA), and 1147 had glioblastoma multiforme (GBM)
Patients with OA3 survived significantly longer than those with OA4 or AA
Patients with OA4 lived significantly longer than those with GBM
The same differences were noted for PFS
Prognostic factors for survival were histology, age, ECOG performance score, and extent of surgical resection, but not treatment administered

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