New cytotoxic rosamine derivatives selectively accumulate in the mitochondria of cancer cells Lim SH et al. - In subsequent experiments, the para-iodo aryl substituted rosamine was found to localize exclusively within the mitochondria and induced apoptosis as the major mode of cell death. The results suggest that these compounds offer potential for the design of mitochondria-targeting agents that either directly kill or deliver cytotoxic drugs to selectively kill cancer cells. [more...]
