Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells
Friedman L et al. - In a study to test the efficacy of FLLL11 and FLLL12 in human pancreatic cancer (PCa) cell lines and compare the impact of curcumin with FLLL11 and FLLL12 on cell viability in PCa cell lines, it was found that the curcumin analogues, FLLL11 and FLLL12, are more effective than curcumin in inhibiting cell viability and inducing apoptosis, and may have translational potential as chemopreventive or therapeutic agents for PCa. Methods- The efficacy of 2 analogues, FLLL11 and FLLL12, were tested in human PCa cell lines.
- The impact of curcumin with FLLL11 and FLLL12 was compared on cell viability in 5 different PCa cell lines.
Results- Although all 3 compounds were capable of lowering viability in all cell lines tested, FLLL11 and FLLL12 were substantially more potent than curcumin.
- FLLL11 and FLLL12 inhibited phosphorylation of signal transducer and activator of transcription 3 and AKT.
- FLLL11 and FLLL12 were found to be more effective than curcumin in inducing apoptosis as evidenced by increased cleavage of PARP and caspase-3 in PCa cell lines.
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