Tumour suppression by p53: the importance of apoptosis and cellular senescence
Zuckerman V et al. - Therapeutic strategies aimed at reactivation of p53 in tumours emerge as a promising approach for the treatment of cancer patients. This response involves transcriptional activation or repression of target genes, as well as the recently identified microRNAs, and transcription-independent functions. Importantly, p53 loss of function is required for tumour maintenance. [more...]
|
|
|
