Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal and gastrointestinal origin shows acceptable morbidity and high survival
Hagendoorn J et al. - In a study to examine the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal carcinomatosis of colorectal and gastrointestinal origin, it was concluded that in well-selected pts referred to a specialized institution, CS–HIPEC has acceptable morbidity and high survival rate. Methods- 67 pts underwent a laparotomy.
- Complete cytoreduction could be performed in 49 pts, who underwent 53 CS–HIPEC procedures.
- All had peritoneal carcinomatosis originating from primary colorectal, cecal, appendiceal, and gastric tumors.
Results- In pts who underwent CS–HIPEC, an R0 resection could be achieved in 4%, R1 in 88%, and R2 in 8%.
- 30-day mortality was 0; 1 pt died in-hospital after 10 wks.
- Median hospital stay was 12 days.
- Overall morbidity was 43%, including extended gastroparesis (11%), anastomotic failure (11%), and intra-abdominal abscess (9%).
- Mean time to clinical recurrence was 12 mos.
- Actuarial 1-yr survival was 88% and 2-yr survival was 75%.
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