Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation Graziano C et al. - Association of these events gives a strong hint of the in vivo involvement of thrombopoietin in vasculogenesis, confirming the role of TPO in human development of the hemangioblast, the embryonic progenitor of the hematopoietic and endothelial lineages. This is the first report showing that vascular disruptions could be secondary to specific gene derangements. [more...]
