Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women
Alokail MS et al. – Obesity and type 2 diabetes, owing to their effects on adipocytokines and inflammatory mediators, contribute to increased breast cancer risk in premenopausal women. This study emphasizes healthy life style and better management of these metabolic disorders to avoid the pathogenesis of breast cancer and of other chronic diseases.Methods- Study to determine the association between obesity and type 2 diabetes with BCa risk in premenopausal women
- Women (n=101) were categorized as obese, overweight and normal body weight based on BMI
- Serum levels of IL-6, TNF-α CRP, leptin, TGF-α adiponectin and insulin were measured by ELISA
- Data were logarithmically transformed for variables not normally distributed
- Analysis of variance with post-hoc Bonferroni was applied to compare the data between the groups
Results- Increased levels of IL-6, CRP, leptin and decreased levels of adiponectin were found in obese group
- Levels of TNF-α and TGF-α were unaltered
- A positive correlation between waist circumference and IL-6 was found in obese group
- Similarly, CRP, waist and hip circumferences were linearly correlated with BMI in obese group
- Stepwise multiple linear regression analysis revealed several significant predictors for BCa risk
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