Predictors of avascular necrosis of bone in long-term survivors of hematopoietic cell transplantation Campbell S et al. - For allogeneic transplant recipients, male sex; presence of chronic graft-versus-host disease; and exposure to CSA, FK506, prednisone, and MMF rendered patients at increased risk, especially in patients with a history of exposure to >=3 drugs. Future studies examining the pathogenetic mechanism underlying AVN should help develop targeted interventions to prevent this chronic debilitating condition. [more...]
