Clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia
Lazic J et al. - In a study to explore clinical features of the most common fusion genes in childhood acute lymphoblastic leukemia (ALL), study results offered additional evidence of variable incidence and clinical characteristics of ALL subtypes. Methods- The study enrolled 70 pediatric pts with de novo ALL, analyzed using reverse transcriptase-polymerase chain reaction for the presence of 4 major risk-stratifying translocations (BCR/ABL, MLL/AF4, TEL/AML1, and E2A/PBX1).
- Bone marrow samples were collected at diagnosis, at the end of induction phase, and after intensive chemotherapy in order to establish a correlation between chromosomal aberration, clinical features, and treatment response.
Results- The results of this study offer more evidence of variable incidence and clinical characteristics of ALL subtypes.
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