Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
Lopes FCM et al. - A significant decrease in proliferation and invasion capacity and an effective increase in apoptosis as assessed by bromodeoxyuridine (BrdU), double-chamber and terminal transferase dUTP nick end labeling (TUNEL) assay, respectively, have been found. Pt also led to a drastic reduction in the number of capillary-like structures formation when HUVEC were cultured on growth factor reduced-Matrigel (GFR-Matrigel) coated plates. In addition, incubation of HUVEC with Pt resulted in reduced NF-kappa B activity. These findings emphasize the potential use of Pt against pathological situations where angiogenesis is stimulated as tumor development. [more...]
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