TA-MUC1 epitope in non-small cell lung cancer
Kuemmel A et al. - In a study to determine the clinical relevance of carbohydrate-induced conformational tumor-associated MUC1 epitope (TA-MUC1) in lung cancer, it seems that the presence of TA-MUC1 is a favorable prognostic factor in this cohort of NSCLC pts, in particular if lymph node metastases are present Methods- 85 paraffin-embedded tissue sections of NSCLC pts were stained with the monoclonal antibody PankoMab (against TA-MUC1) and compared with the established antibodies E29 and 214D4 regarding prognostic relevance
Results- TA-MUC1 is virtually absent in bronchial epithelium
- Only staining with PankoMab, but not with E29 or 214D4, was correlated with pts’ survival
- When regarding interactions of MUC1 antibody staining results and clinico-pathological parameters, pts with lymph node metastasis lacking PankoMab staining were attributed the highest risk
[more...]
|
|
|
