Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers
Ota, T., et al. - In a study to determine the survival rate, incidence of late complications, and incidence of second cancers when radiation therapy alone is used for carcinoma of the uterine cervix, it was found that this method of radiation therapy alone for locally advanced carcinoma of the uterine cervix is effective, with low incidences of late complications and second cancers
Methods
- 1495 patients with squamous cell carcinoma of the uterine cervix (stages I-IV) were treated with radiation therapy alone
- Radiation therapy consisted of a combination of high-dose-rate intracavitary brachytherapy and external beam radiotherapy
Results
- Cumulative 5-year survival rates for stages Ib, II, and III/IVa carcinoma were 93.5, 77.0, and 60.3%, respectively
- 10-year survival rates were 90.9, 74.5, and 56.1%, respectively
- Local control rates for stages Ib, II, and III/IVa carcinoma were 92.0, 79.4 and 64.2%, respectively
- 5.5% of patients suffered grade III/IV or V (fatal) complications
- A second cancer developed in 0.87% of patients
- Second cancers were observed most frequently in the rectum (5 cases), colon (3 cases), and uterine body (2 cases)
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