Over-expression of PTEN sensitizes human ovarian cancer cells to cisplatin-induced apoptosis in a p53-dependent manner Xiaojuan Yan, et al. - Resistance to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer...Conclusion: Taken together, these data suggest that PTEN over-expression may represent a novel therapeutic approach for chemoresistant human ovarian cancer and that this may involve a p53-mediated apoptotic cascade independent of the PI3K/Akt pathway [more...]
