Top hcc Articles in Oncology

XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk
BMC Cancer, 11/20/2009

in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of hepatocellular carcinoma (HCC) related to the exposure of aflatoxin B1 (AFB1). In this study, we have focused on the polymorphisms of xeroderma pigmentosum complementation group D (XPD ... polymorphism is an important modulator of AFB1 related-HCC development. Methods Case-control study including 618 HCC cases and 712 controls to evaluate the associations between these 2 polymorphisms and HCC risk for Guangxi population by means of TaqMan-PCR and PCR-RFLP ... featuring XPD genotypes with codon 751 Gln alleles (namely XPD-LG or XPD-GG) related to elevated risk of HCC compared to those with homozygote of XPD codon 751 Lys alleles [namely XPD-LL, adjusted odds ratios (ORs) 1.75 and 2.47; 95% confidence interval (CIs) were 1.30 - 2.37 and 1.62 - 3.76 ... OR = 2.90 for XPD-GG) Interactive effects of polymorphism and AFB1-exposure information showed codon 751 Gln alleles increase risk of HCC for individuals facing longer exposure years (Pinteraction = 0.011, OR = 0.85) Long-exposure-years (> 48 years) individuals who carried XDP-GG ... codon 312 polymorphism significantly associated with HCC risk [more...]

EFNA1 ligand and its receptor EphA2: Potential biomarkers for hepatocellular carcinoma
International Journal of Cancer, 11/09/2009

and progression evaluation of hepatocellular carcinoma (HCC).The purpose of this study was to identify useful biomolecular markers for HCC. The 26 genes that encode EFNA1 and EphA2 may be useful serum markers for the detection of HCC development and progression, respectively. Methods HCC Results EFNA1 mRNA overexpressed in most HCCs as compared with expression in corresponding nontumor tissues (36 out of 40 cases, 90%), but EphA2 expression was noted in only half of HCC tissues (20 of 40 cases, 50%) In most ... cultured hepatoma cells and in serum of patients with HCC EphA2 expression prominent in highly invasive hepatoma cells, and its overexpression significantly correlated with decreased differentiation (r = 0.0248) and poor survival for HCC patient [more...]

Excellent outcomes with angiographic subsegmentectomy in the treatment of typical hepatocellular carcinoma
Cancer, 11/16/2009

treatment for hepatocellular carcinoma (HCC) referred to as angiographic subsegmentectomy (AS). This treatment involved simultaneous embolization of the peripheral feeding artery and the portal vein. The result was that almost all of the HCC and peripheral liver parenchyma developed complete ... li>Retrospective study of the local recurrence rates of 49 solitary HCCs and long-term survival rates of 120 patients with HCC between 2000 and 2008 Results Results indicated that, in 31 small, solitary HCCs (< 2.0 cm), local recurrence rate was only 9.6% In 10 ... patients with stage I and stage I/Child-Pugh grade A HCC 74.27% and 77.65%, 53.05% and 51.76%, and 53% and 51.76%, respectively 5-year, 8-year, and 10-year survival rates for patients with stage II and stage II/Child-Pugh grade A HCC were 66.21% and 71.41%, 39.9% and 39.60%, and 29.92% and [more...]

Genomic aberrations in hepatocellular carcinoma related to osteopontin expression detected by array-CGH
Journal of Cancer Research & Clinical Oncology, 10/23/2009

There is a significant intratumor genomic heterogeneity between the OPN–positive and negative HCC cells, and OPN–positive HCC cells play a more important role in the development of HCC malignancy than their OPN–negative counterparts. [more...]

Prognostic factors and recurrence of hepatitis B-related hepatocellular carcinoma after argon-helium cryoablation: a prospective study
Clinical and Experimental Metastasis, 10/02/2009

The expression of VEGF in HCC tissues and HBV BCP mutations were found to be independent prognostic factors for recurrence–free survival. Strong expression of VEGF in HCC tissues and HBV BCP mutations are important risk predictors for recurrence or metastasis of HCC smaller than 5 cm in [more...]

Liver transplantation for HCC: its role
Journal of Hepato-Biliary-Pancreatic Surgery, 11/09/2009

Hwang S et al. – The eligibility criteria of both DDLT and LDLT for HCC are likely to be expanded more than before, but this still requires further qualified risk–benefit analyses. The development of new effective treatment modalities before LT and for HCC recurrence might [more...]

Recurrence of hepatocellular carcinoma and hepatitis B reinfection in hepatitis B surface antigen-positive patients after liver transplantation
Liver Transplantation, 11/03/2009

al. – Pre–OLT HCC and HCC recurrence after transplantation were associated with HBV reinfection and with decreased patient survival. Hepatitis B immunoglobulin and antiviral therapy was only partially effective in preventing HBV reinfection in patients with HCC recurrence [more...]

Multidetector-row computed tomography (MDCT) for the diagnosis of hepatocellular carcinoma in cirrhotic candidates for liver transplantation: prevalence of radiological vascular patterns and histological correlation with liver explants
European Radiology, 10/06/2009

by MDCT can be confidently considered to be HCC. Hyper–L larger than 10 mm and Hypo–L of 20 mm or larger are at high risk of HCC. However, even using MDCT and the newest imaging protocols, imaging underestimated the diagnosis of small HCC. [more...]

Role of Hepatitis B Virus Infection in the Prognosis After Hepatectomy for Hepatocellular Carcinoma in Patients With Cirrhosis
Archives of Surgery, 10/20/2009

for lower RFS after hepatectomy for a single nodule of HCC of 5 cm or smaller in patients with cirrhosis, providing a further basis for adjuvant antiviral treatment. Patients who are seropositive for HBV with poorly differentiated HCC should also be considered to be at a high risk of recurrence and [more...]

Predictors and prognostic significance of operative complications in patients with hepatocellular carcinoma who underwent hepatic resection
European Journal of Surgical Oncology, 10/21/2009

of complications after hepatic resection for HCC. Long–term survival is poorer in patients with postoperative complications. Decreasing operative blood loss may result in fewer postoperative complications and better long–term survival of HCC patients. [more...]