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See Latest ArticlesSelf-reported outcomes during treatment with tumour necrosis factor [agr] inhibitors in patients with rheumatoid arthritis
Musculoskeletal Care, 11/16/09
Bala SV et al. – During the first year of treatment with TNF -&alpha inhibitors, patients reported decreased fatigue, morning stiffness and pain, while their capacity increased. The increased capacity rate closely followed the decrease in symptom rate.
Methods- 39 patients, who were being treated for their RA in our outpatient rheumatology clinic and were beginning treatment with TNF- &alpha inhibitors, agreed to evaluate and self-report their experience of fatigue, morning stiffness, pain, and capacity using visual analogue scale (VAS) every third month during their first year of treatment
- Quantitative method used to study changes in these 4 variables
- Relationship between self-reported capacity and each of 3 symptoms
- After 12 months' treatment with TNF-&alpha inhibitors, the change (median interquartile range [IQR]) measured with VAS was -14 (-38, -7) mm for fatigue, -22 (-47, -4) mm for morning stiffness, -28 (-50, 0) mm for pain and -27 (-48, -6) mm for capacity. All changes were statistically significant
- Baseline and 12 months' capacity correlated significantly with fatigue, morning stiffness and pain
- Median change in self-reported capacity correlated significantly with median change in each of 3 symptoms
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