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Systematic Review: Comparative Effectiveness and Harms of Combination Therapy and Monotherapy for Dyslipidemia
Annals of Internal Medicine, 11/03/09
Sharma M et al. – This review of 102 studies found 2 trials that suggested lower target lipid levels were more often achieved with statin–ezetimibe combination therapy than with high–dose statin monotherapy. No firm trial evidence showed that combining a statin with another agent (bile–acid sequestrant, fibrate, ezetimibe, niacin, or omega–3 fatty acids) improved clinical outcomes (myocardial infarction, stroke, or mortality) more often than high–dose statin monotherapy.
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