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Diagnosis and Treatment of Viral Myocarditis
Mayo Clinic Proceedings, 11/03/09

Schultz JC et al. – Myocarditis, an inflammatory disease of heart muscle, is an important cause of dilated cardiomyopathy worldwide. Viral infection is also an important cause of myocarditis, and the spectrum of viruses known to cause myocarditis has changed in the past 2 decades. Several new diagnostic methods, such as cardiac magnetic resonance imaging, are useful for diagnosing myocarditis. Endomyocardial biopsy may be used for patients with acute dilated cardiomyopathy associated with hemodynamic compromise, those with life–threatening arrhythmia, and those whose condition does not respond to conventional supportive therapy. Important prognostic variables include the degree of left and right ventricular dysfunction, heart block, and specific histopathological forms of myocarditis. The authors review diagnostic and therapeutic strategies for the treatment of viral myocarditis. English–language publications in PubMed and references from relevant articles published between January 1, 1985, and August 5, 2008, were analyzed. Main keywords searched were myocarditis, dilated cardiomyopathy, endomyocardial biopsy, cardiac magnetic resonance imaging, and immunotherapy.

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Cardiac troponin-I as a screening tool for myocarditis in children hospitalized for viral infection
Acta Pediatrica, 11/16/09 Relevance Score: 68%

Non-invasive imaging in the diagnosis of acute viral myocarditis
Clinical Research in Cardiology, 10/05/09 Relevance Score: 64%

The Proteasome Inhibitor Bortezomib Enhances the Susceptibility to Viral Infection
Journal of Immunology, 11/13/09 Relevance Score: 45%

Mutational Analysis Reveals a Noncontractile but Interactive Role of Actin and Profilin in Viral RNA-Dependent RNA Synthesis
Journal of Virology, 10/13/09 Relevance Score: 45%

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection
Journal of Experimental Medicine, 10/05/09 Relevance Score: 45%