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Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage
Journal of Neurosurgery, 11/09/09
Park IS et al. – Subarachnoid hemorrhage led to a persistent impairment of endothelium–dependent dilation and a transient attenuation of vascular smooth muscle–dependent dilation responses to adenosine. Impairment of NOmediated dilation occurred when the response to cGMP was intact, suggesting a change in cGMP levels rather than an alteration in intracellular mechanisms downstream from cGMP.
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