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See Latest ArticlesInflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09
Rho YH et al. – TNF&alpha and IL-6 are significantly associated with the severity of subclinical atherosclerosis, independent of Framingham risk score, in RA.
Methods- Clinical variables, concentrations of inflammatory mediators, and coronary artery calcification measured in 169 patients with RA and 92 control subjects
- Differences in concentrations of inflammatory mediators were compared using median quantile regression
- Relationship of inflammatory mediators with severity of coronary calcification in RA and control subjects examined using proportional odds logistic regression, allowing for interaction with disease status
- Models were adjusted for traditional cardiovascular risk factors
- Median serum concentrations of IL-6, SAA, ICAM-1, E-selectin, TNF&alpha , and MPO and peripheral blood neutrophil count were higher in patients with RA than controls , independent of Framingham risk score and diabetes mellitus (DM). IL-6 (main effect odds ratio [OR] 1.72; 95% confidence interval [95% CI] 1.12, 2.66) and TNF&alpha concentrations were significantly associated with higher amounts of coronary calcium, independent of Framingham risk score and DM, and such main effects significantly differed from controls
Today in Atherosclerosis/Lipids...keeping you current
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Nutritional supplements and serum lipids: Does anything work
Current Atherosclerosis Reports, 11/16/09
Systematic Review: Comparative Effectiveness and Harms of Combination Therapy and Monotherapy for Dyslipidemia
Annals of Internal Medicine, 11/03/09
Rosuvastatin along the cardiovascular continuum: from JUPITER to AURORA
Expert Review of Cardiovascular Therapy , 11/16/09
Today in Basic Science/Genetics...keeping you current
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A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
The Lancet, 10/27/09
Obesity-Related Cardiorenal Syndrome
The Journal of Clinical Hypertension, 10/20/09
Benefits and Difficulties in Measuring HDL Subfractions and Human Paraoxonase-1 Activity During Statin Treatment
Cardiovascular Drugs and Therapy, 11/03/09
Today in Inflammation...keeping you current
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Arterial stiffness and cumulative inflammatory burden in rheumatoid arthritis: A dose-response relationship independent of established cardiovascular risk factors
Rheumatology, 10/28/09
Acute Decline in Renal Function, Inflammation, and Cardiovascular Risk after an Acute Coronary Syndrome
Clinical Journal of the American Society of Nephrology, 11/13/09
Hemostasis, Inflammation, and Fatal and Nonfatal Coronary Heart Disease. Long-Term Follow-Up of the Atherosclerosis Risk in Communities (ARIC) Cohort
Arteriosclerosis, Thrombosis, and Vascular Biology, 10/26/09
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