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HO-1 and CO Decrease Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cell Migration Via Inhibition of Nox1
Arteriosclerosis, Thrombosis, and Vascular Biology, 11/02/09
Rodriguez AI et al. – The authors demonstrate that increased HO–1 expression and CO decreases platelet–derived growth factor–stimulated VSMC migration via inhibition of Nox1 enzymatic activity. These studies reveal a novel mechanism by which HO–1 and CO may mediate their beneficial effects in arterial inflammation and injury.
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