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See Latest ArticlesAngiotensin II–Induced Oxidative Stress Resets the Ca2+ Dependence of Ca2+–Calmodulin Protein Kinase II and Promotes a Death Pathway Conserved Across Different Species
Circulation Research, 11/03/09
Palomeque J et al. – The Ang II–induced apoptotic cascade converges in both species, in a common pathway mediated by ROS–dependent CaMKII activation which results in p38MAPK activation and apoptosis. In the presence of Ang II or ROS, CaMKII may be activated at subdiastolic Ca2+ concentrations, suggesting a new mechanism by which ROS reset the Ca2+ dependence of CaMKII to extremely low Ca2+ levels.
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