Cardiology Medical News about Aortic Aneurysm, Abdominal

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Binding Sites for Ets Family of Transcription Factors Dominate the Promoter Regions of Differentially Expressed Genes in Abdominal Aortic Aneurysms
Circulation: Cardiovascular Genetics, 10/22/09

Nischan J et al. – The genome–wide analysis provides further evidence of ETS and NFKB involvement in AAA. Additionally, the results provide novel insight for future studies aiming to dissect the pathogenesis of AAA and have uncovered potential therapeutic targets for AAA prevention.

Exclusive Author Commentary
Helena Kuivaniemi, 10/22/09

Abdominal aortic aneurysms (AAAs) are a chronic disease whose pathogenesis is poorly understood. The lack of knowledge about the underlying molecular mechanisms is hampering the development of treatment modalities. Currently surgical intervention is successful, but is used at a late stage of the disease leaving patients with small AAAs in the unpleasant situation of having to “wait and see” until the AAA has grown large enough for the risk of rupture and its attendant morbidity and mortality to outweigh the interventional risk. Development of methods to slow down the growth of small AAAs requires better understanding of the molecular pathways involved in this process. We previously carried out a whole-genome-based expression analysis comparing aortic tissue samples obtained from patients with AAAs to those without the disease and identified 3,274 genes whose expression was significantly decreased or increased in the AAA tissue. The current study used a genome-wide approach to analyze the control regions of the genes over-represented in AAA with the goal of finding transcriptional elements responsible for driving gene expression. We showed that the promoters were enriched for binding sites of a small number (N=13) of transcription factors, suggesting co-regulation and a significant role in the pathogenesis of AAAs. We confirmed protein expression of these transcription factors in control aorta and AAA tissue by immunohistochemical staining. These types of genome-wide analyses are critical for the identification of potential targets for new pharmacological therapies to assist in the prevention and management of this deadly disease.

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Hemorphin 7 Reflects Hemoglobin Proteolysis in Abdominal Aortic Aneurysm
Arteriosclerosis, Thrombosis, and Vascular Biology, 11/17/09 Relevance Score: 81%

Acute Thrombosis of Abdominal Aortic Aneurysm During Cardiac Surgery
Annals of Thoracic Surgery, 11/06/09 Relevance Score: 81%

The Influence of Different Types of Stent Grafts on Aneurysm Neck Dynamics after Endovascular Aneurysm Repair
European Journal of Vascular and Endovascular Surgery, 11/11/09 Relevance Score: 80%

A New Preoperative Predictor of Outcome in Ruptured Abdominal Aortic Aneurysms: The Time Before Shock
Annals of Vascular Surgery, 11/10/09 Relevance Score: 80%

Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromso study
International Journal of Epidemiology, 11/09/09 Relevance Score: 80%