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Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone
JACC - Journal of the American College of Cardiology, 10/23/09
Mak GJ et al. – This study demonstrates progressive increases in markers of collagen turnover and inflammation in HFPSF with diastolic dysfunction. Despite high background utilization of renin–angiotensin–aldosterone modulators, eplerenone therapy prevents a progressive increase in pro–collagen type–III aminoterminal peptide and may have a role in management of this disease.
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