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Antiplatelet therapy for prevention of recurrent stroke
Current Treatment Options in Neurology, 10/30/09
Badruddin A et al. – When choosing an antiplatelet agent for this purpose, clinicians should take into account cost, side effect profile, medical comorbidity, and patient preference. To prevent recurrent stroke, aspirin alone (50–325 mg/d), a combination of aspirin (25 mg) plus extended–release dipyridamole (200 mg), given twice daily, or clopidogrel (75 mg/d) may be used as initial treatment. Prasugrel, a new thienopyridine derivative, more quickly and consistently inhibits platelets than clopidogrel. In stroke patients, prasugrel may be associated with a higher risk of brain hemorrhage, so it may not be indicated when there is a history of cerebrovascular disease.
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