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Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Research in Cardiology , 10/29/09
Oie E et al. – The data demonstrate increased expression and decreased receptor binding of AM in the lungs in severe HF. Furthermore, the data indicate that alveolar macrophages are an important source of pulmonary AM in both experimental and clinical HF. Finally, a net release of AM from the lungs into the circulation was only found in patients with severe systolic dysfunction.
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