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Serum cardiac Troponin T, but not Troponin I, is elevated in idiopathic inflammatory myopathies
Journal of Rheumatology, 10/20/09
Aggarwal R et al. – Elevated cTnT, but not cTnI, was highly associated with CK in patients with IIM despite the absence of myocardial ischemia.
Methods- Retrospective study
- Patients with IIM followed by rheumatology service of county hospital from 2004 to 2008
- Patients with myocardial ischemia and/or with renal failure excluded
- Clinical data including electromyogram, muscle biopsy, and CK, cTnT and cTnI recorded
- Patients with simultaneous analysis of CK and cardiac troponin (cTnT or cTnI) levels studied
- CK levels correlated with cTnT and cTnI by chi-square test and Spearman correlation
- 49 patients with IIM (69 observations) who satisfied our inclusion criteria identified
- Primary diagnosis polymyositis in 23, dermatomyositis in 16, and myositis associated with connective tissue disease in 10 patients
- 33/49 women with average age 45.8 y
- 28 patients with IIM had simultaneous CK and cTnT values assayed
- 18/23 patients with elevated CK had elevated cTnT, and 5/5 patients with normal CK levels had normal cTnT levels
- In 41 patients with IIM who had simultaneous CK and cTnI levels assayed, only 1/29 with elevated CK had elevated cTnI, and 12/12 patients with normal CK had normal cTnI
- CK correlated strongly with cTnT but did not correlate with cTnI
Today in Basic Science/Genetics...keeping you current
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A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial
The Lancet, 10/27/09
Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09
Obesity-Related Cardiorenal Syndrome
The Journal of Clinical Hypertension, 10/20/09
Today in Inflammation...keeping you current
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Arterial stiffness and cumulative inflammatory burden in rheumatoid arthritis: A dose-response relationship independent of established cardiovascular risk factors
Rheumatology, 10/28/09
Inflammatory mediators and premature coronary atherosclerosis in rheumatoid arthritis
Arthritis Care and Research , 11/03/09
Acute Decline in Renal Function, Inflammation, and Cardiovascular Risk after an Acute Coronary Syndrome
Clinical Journal of the American Society of Nephrology, 11/13/09
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