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See Latest ArticlesAtrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism
Cardiovascular Research, 10/20/09
Glenn DJ et al. – Collectively, these findings suggest that locally produced ET–1 serves as an autocrine stimulator of fibroblast proliferation, that ANP produced in neighbouring myocytes serves as a paracrine inhibitor of this proliferation, and that the latter effect operates through a reduction in GATA4 phosphorylation and coincident reduction in GATA4–dependent transcriptional activity.
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