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Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
Cardiovascular Research, 10/20/09

Lacerda L et al. – The protective effect of the SAFE pathway is shown in IPostC, with the activation of TNF–alpha, its receptor type 2, and STAT–3. This signalling cascade is activated independently of the well–known Reperfusion Injury Salvage Kinases (RISK) pathway, which involves the kinases Akt and Erk1/2.

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Lydia Lacerda, 10/21/09

The SAFE pathway in ischaemic postconditioning is a novel and alternative path to the well-established RISK pathway. TNF alpha, normally considered to be detrimental is shown to initiate a beneficial signalling cascade by binding to its receptor 2, activating STAT-3 and thereby conferring cardioprotection. However, further activation of TNF alpha may not be ideal in certain patients such as those with rheumatoid arthritis and ankylosing spondylitis as well as the diabetic patient where TNF alpha may stimulate insulin resistance. Therefore a better target may be one of the downstream regulators of the SAFE pathway.

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