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See Latest ArticlesRole of reactive oxygen species (ROS) in angiotensin II-induced stimulation of the cardiac Na+/HCO3- cotransport
Journal of Molecular and Cellular Cardiology, 10/21/09
De Giusti VC et al. – The authors propose that Ang II enhances the production of ROS through the activation of the NADPH oxidase, which in turn triggers mKATP opening and mitochondrial ROS production (“ROS–induced ROS–release mechanism”). Finally, these mitochondrial ROS stimulate the ERK pathway, leading to the activation of the NBC.
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