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The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPAR-alpha In Vitro and In Vivo
PLoS ONE - Cardiovascular Disorders, 10/20/09
Wray JA et al. – The results establish that CYP2J2 produces PPAR-alpha ligands in vitro and in vivo, and suggests that lipid metabolising CYPs are prime candidates for the integration of global lipid changes to transcriptional signalling events.
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