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Anticoagulation for heart failure: selecting the best therapy
Expert Review of Cardiovascular Therapy , 10/19/09
Kohsaka S et al. – Warfarin is of proven efficacy in patients with ischemic heart disease and atrial fibrillation, but there has been little research testing antithrombotic agents in patients with HF. Aspirin may be another promising drug, but trials have shown a higher rate of HF admissions with aspirin, suggesting that aspirin may attenuate the angiotensin–converting enzyme inhibitor effect on cardiac function. The authors eagerly await the completion of large, randomized trials to help guide us in these important issues affecting a large number of patients.
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