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See Latest ArticlesShear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ib-alpha shedding
Heart And Circulatory Physiology, 11/02/09
Cheng H et al. – These results indicate that shear–induced platelet–VWF interaction results in calpain and metalloproteinase–dependent GPIb–alpha ectodomain shedding. These findings not only have physiological implication in understanding the presence of glycocalicin in normal circulation, but also suggest a novel mechanism for the negative regulation of platelet function and the limitation of platelet thrombus infinite formation under pathophysiological flow conditions.
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