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Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes
Heart And Circulatory Physiology, 10/16/09
Ares–Carrasco S et al. – Fibrosis and apoptosis are features of long–term myocardial damage in experimental DM1. Associated hypertension does not induce additional changes. Myocardial inflammation is present in hypertension and short–term DM1, but is not a key feature in long–term DM1. Local reduction of pro–inflammatory factors and expression of anti–inflammatory and anti–oxidant molecules may underlie this effect.
Óscar Lorenzo, 10/19/09
| Anti-inflammatory and/or anti-oxidant specific molecules may be used as a therapy for damaged hearts from diabetic and hypertensive patients. |
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