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Generation of nitric oxide from nitrite by carbonic anhydrase: A possible link between metabolic activity and vasodilation
Heart And Circulatory Physiology, 10/23/09
Aamand R et al. – The results reveal a novel nitrous anhydrase enzymatic activity of CA that would function to link in vivo main end–products of energy metabolism (CO2/H+) to generation of vasoactive NO. The CA–mediated NO production may be important to the correlation between blood flow and metabolic activity in tissues, as occurring for instance in active areas of the brain.
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