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Spiral Waves and Reentry Dynamics in an In Vitro Model of the Healed Infarct Border Zone
Circulation Research, 10/22/09
Chang MG et al. – Cocultures reproduce several architectural and electrophysiological features of the healed IBZ. Reentry termination by L–type Ca2+ channel, but not Na+ channel, blockers suggests a greater Ca2+–dependence of propagation. These results may help explain the low efficacy of pure Na+ channel blockers in preventing and terminating clinical VTs late after MI.
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