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Using Nontraditional Risk Factors in Coronary Heart Disease Risk Assessment: U.S. Preventive Services Task Force Recommendation Statement
Annals of Internal Medicine, 10/06/09

For this review, the USPSTF addressed the health benefits, including reduction in CHD events, CHD mortality, and overall mortality, of applying nontraditional risk factors to those identified as intermediate–risk by the Framingham CHD risk algorithm. The current evidence is insufficient to assess the balance of benefits and harms of using the nontraditional risk factors studied to screen asymptomatic men and women with no history of CHD to prevent CHD events. (I statement). The nontraditional risk factors included in this recommendation are high–sensitivity C–reactive protein (hs–CRP), ankle–brachial index (ABI), leukocyte count, fasting blood glucose level, periodontal disease, carotid intima–media thickness (carotid IMT), coronary artery calcification (CAC) score on electron–beam computed tomography (EBCT), homocysteine level, and lipoprotein(a) level.

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