Cardiology Medical News about Hypertension, Pulmonary

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Bosentan: A Review of its Use in the Management of Mildly Symptomatic Pulmonary Arterial Hypertension
American Journal of Cardiovascular Drugs, 10/08/09

Dhillon S et al. – Oral bosentan therapy was beneficial and generally well tolerated in patients with mildly symptomatic PAH. In a well designed, placebo–controlled trial in adolescents and adults with mildly symptomatic PAH, pulmonary vascular resistance was significantly reduced with bosentan relative to placebo, but the 6–minute walk distance did not increase significantly. Similarly, pediatric patients (most of whom had mildly symptomatic PAH) in a small uncontrolled trial experienced some improvement in hemodynamic variables with bosentan, but did not experience a significant increase in exercise capacity. Adverse events associated with bosentan were consistent with those seen in other indications, with major concerns being the potential for teratogenicity and hepatotoxicity, for which regular liver function monitoring is recommended. Overall, considering the progressive nature of PAH, bosentan extends the treatment options available to patients with mildly symptomatic PAH.

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Sarcoidosis-Associated Fibrosing Mediastinitis with Resultant Pulmonary Hypertension: A Case Report and Review of the Literature
Respiration, 10/06/09 Relevance Score: 70%

Role of Epidermal Growth Factor Inhibition in Experimental Pulmonary Hypertension
American Journal of Respiratory and Critical Care Medicine, 10/27/09 Relevance Score: 69%

New finding could lead to cure of pulmonary arterial hypertension
Internet Source, 10/26/09 Relevance Score: 69%

Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease
British Journal of Haematology, 10/05/09 Relevance Score: 69%

The Use of Sildenafil in Persistent Pulmonary Hypertension of the Newborn
American Journal of Perinatology, 10/28/09 Relevance Score: 68%