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See Latest ArticlesGene Therapy With the Angiogenic Cytokine Secretoneurin Induces Therapeutic Angiogenesis by a Nitric Oxide–Dependent Mechanism
Circulation Research, 10/08/09
Schgoer W et al. – The data indicate that gene therapy with secretoneurin induces therapeutic angiogenesis, arteriogenesis, and vasculogenesis in the hindlimb ischemia model by a nitric oxide–dependent mechanism.
Rudolf Kirchmair M.D., 10/13/09
| We recently could show that the neuropeptide secretoneurin (SN) induces angiogenesis and is upregulated in ischemic muscle cells. In the current work we demonstrated that SN gene therapy induces therapeutic angiogenesis in an animal model of peripheral arterial disease, the mouse hindlimb ischemia model. SN improved blood flow and clinical outome (necrosis and movement score) and increased density of capillaries, arteries and endothelial progenitor cells in ischemic muscles. SN stimulated nitric oxide (NO) synthesis and inhibition of NO attenuated beneficial effects of SN gene therapy in-vivo. In summary, our data indicate that SN gene therapy induces therapeutic neovascularization and might be a promising new therapeutic option to treat patients suffering from critical limb ischemia. |
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