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Blood Pressure and Brain Injury in Older Adults: Findings from a Community-Based Autopsy Study
Journal of the American Geriatrics Society, 09/30/09

Wang LY et al. – The association between high systolic (SBP) and cerebrovascular damage in untreated older adults (65–80) suggests that adequate hypertension treatment may reduce dementia risk by minimizing microvascular injury to cerebrum.

Methods

Prospective cohort study.
A cohort of 250 participants aged 65 and older and cognitively normal at time of enrollment in the Adult Changes in Thought (ACT) Study and who underwent autopsy.
BP and history of antihypertensive treatment were taken at enrollment. A linear regression model was used to examine the relationship between BP (systolic (SBP) and diastolic (DBP)) at enrollment and pathological changes in the cerebrum (cystic macroscopic infarcts, microinfarcts, neuritic plaques, neurofibrillary tangles, and cortical Lewy bodies).

Results

The presence of more than 2 microinfarcts, but not any other pathological change, was independently associated with SBP in younger participants but not in older participants.
The relative risk (RR) for more than two microinfarcts with each 10–mmHg increase in SBP was 1.15 in the younger participants, adjusted for age at entry, sex, and time to death.
This RR was particularly strong in younger participants not taking antihypertensive medications; significant associations were not observed in participants treated for hypertension. Findings for DBP were negative.

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