Cardiology Medical News about Heart Failure, Systolic

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Dysfunctional Corin I555 (P568) Allele is Associated with Impaired BNP Processing and Adverse Outcomes in African-Americans with Systolic Heart Failure: Results from the Genetic Risk Assessment in Heart Failure A-HeFT Sub-Study
Circulation: Heart Failure, 09/30/09

Rame JE et al. – The authors have identified a pharmacogenomic interaction in African–Americans with systolic heart failure. The corin I555(P568) allele is associated with an increased risk for death or heart failure hospitalization in patients receiving standard neurohormonal blockade, but the addition of fixed dose combination isosorbide–dinitrate/hydralazine (FDC I/H) ameliorates this risk. A plausible mechanism for this pharmacogenomic interaction is the impaired processing of BNP in carriers of the corin I555(P568) allele as compared to non–carriers.

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