Cardiology Medical News about Cardiovascular Diseases Clofibric Acid Lipids Review

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death

3. The Job Market for 2008-2009: Compensation

4. Renal Artery Stenosis

5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Effect of Fibrates on Lipid Profiles and Cardiovascular Outcomes: A Systematic Review
American Journal of Medicine, 09/29/09

Abourbih S et al. – In addition to improving lipid profiles, fibrates are associated with an important decrease in nonfatal myocardial infarction, but do not substantially affect all–cause mortality. Potential applications include treatment for patients with statin resistance or isolated hypertriglyceridemia, or as an adjunct to other lipid–lowering therapies.

Methods

The authors systematically searched the literature to identify randomized, double–blind, placebo–controlled trials examining the effect of fibrates on lipid profiles or cardiovascular outcomes
The authors estimated the effect of fibrates on the incidence of nonfatal myocardial infarction and all–cause mortality using random effects models.

Results

Compared with placebo, fibrates were associated with greater reductions in total cholesterol (range: ?101.3 mg/dL to ?5.0 mg/dL) and triglycerides (range: ?321.3 mg/dL to ?20.8 mg/dL), and a greater increase in high–density lipoprotein (range: +1.1 mg/dL to +17.9 mg/dL) in all trials.
Fibrates tended to be associated with a greater reduction in low–density lipoprotein (range: ?76.3 mg/dL to +38.7 mg/dL) than placebo, although these results were not consistent across all trials.
Fibrates were more efficacious than placebo at preventing nonfatal myocardial infarction, but not all–cause mortality.

<< Previous
Coronary risk estimates and decisions on lipid-lowering treatment...

Next >>
Depression and Heart Failure