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Differential Regulation of Vascular Smooth Muscle and Endothelial Cell Proliferation In Vitro and In Vivo by cAMP/PKA-activated p85-alpha-PI3K
Heart And Circulatory Physiology, 10/07/09
Torella D et al. – PKA–activated–p85–alpha integrates cAMP/PKA signaling differently in VSMCs and ECs. By reducing neointimal hyperplasia without inhibiting endothelial regeneration, it exerts a protective effect against restenosis after balloon injury.
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