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See Latest ArticlesMechanisms Underlying Skeletal Muscle Weakness in Human Heart Failure: alterations in Single Fiber Myosin Protein Content and Function
Circulation: Heart Failure, 10/07/09
Miller MS et al. – Collectively, the results show that heart failure alters the quantity and functionality of the myosin molecule in skeletal muscle, leading to reduced tension in MHC I fibers. Loss of single fiber myosin protein content represents a potential molecular mechanism underlying muscle weakness and exercise limitation in heart failure patients.
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