Cardiology Medical News

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Pre-participation screening of young competitive athletes for prevention of sudden cardiac death

3. The Job Market for 2008-2009: Compensation

4. Renal Artery Stenosis

5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Metabolic syndrome, endothelial injury, and subclinical atherosclerosis in patients with systemic lupus erythematosus
Scandinavian Journal of Rheumatology , 09/28/09

Mok CC et al. – The MetS is more prevalent in SLE patients than the general population and is associated with endothelial injury and coronary atherosclerosis. More aggressive control of risk factors is justified in these patients.

Methods

Consecutive SLE patients without a history of arterial thrombosis
Screened for atherosclerosis carotid and coronary arteries by B-mode ultrasound
Plasma levels of homocysteine, high-sensitivity C-reactive protein (hsCRP), soluble vascular cell adhesion molecule (sVCAM)-1, P-selectin, and soluble thrombomodulin (sTM) assayed
Patients stratified according to National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria for MetS, using the Asian criteria for abdominal obesity
Risk factors for atherosclerosis studied

Results

Of 123 SLE patients (93% women; age 47.9±11 years; SLE duration 10.9±7.0 years) studied, 20 (16.3%) had MetS
Prevalence of MetS in SLE patients was significantly higher than in 492 age- and sex-matched healthy controls (9.6%)
Coronary calcification and abnormal carotid IMT detected in 38 (31%) and 72 (59%) of SLE patients
Patients with MetS had significantly higher Agatston score and a numerically higher carotid IMT than those without
Using logistic regression model, the MetS [odds ratio (OR) 3.11, 95% confidence interval (CI) 1.01-9.59, p=0.049] associated with coronary atherosclerosis after adjustment for age and other risk factors
Patients with MetS had significantly higher levels of hsCRP , homocysteine , and sTM

<< Previous
Cardiovascular and biochemical risk factors for incident dementia...

Next >>
Quality of Care for Atrial Fibrillation Among Patients...