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See Latest ArticlesMaternal EDN1 G5665T polymorphism influences circulating endothelin-1 levels and plays a role in determination of preeclampsia phenotype
Journal of Hypertension, 10/05/09
Aggarwal PK et al. – Maternal endothelin–1 is elevated and correlates with the severity of blood pressure elevation in preeclampsia. The endothelin–1 is likely released from the maternal endothelium. Presence of T allele at 5665 position in maternal EDN1 gene is associated with higher endothelin–1 levels. Placental endothelin–1 synthesis is reduced in preeclampsia. The combination of elevated maternal and reduced placental endothelin–1 may be an adaptive response to reduced uteroplacental flow in preeclampsia.
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