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Role of Ca2+/Calmodulin–Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy
Circulation Research, 10/06/09
Miller CL et al. – The results elucidate a novel role for Ca2+/CaM–stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG–dependent mechanism, thereby demonstrating Ca2+ and cGMP signaling cross–talk during cardiac hypertrophy.
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