Cardiology Medical News about Endoluminal Vessel Injury

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Nitro-Fatty Acid Inhibition of Neointima Formation After Endoluminal Vessel Injury
Circulation Research, 10/06/09

Cole MP et al. – Electrophilic nitro–fatty acids induce salutary gene expression and cell functional responses that are manifested by a clinically significant outcome, inhibition of neointimal hyperplasia induced by arterial injury.

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Philip M. Bauer, 10/08/09

Nitro-fatty acid derivatives are one class of lipid oxidation byproducts generated by nitric oxide-mediated inflammatory reactions. Evidence suggests the robust and reversible electrophilic reactivity of nitro-fatty acids results in transcriptional activation and post-translational protein modifications that promote the resolution of inflammation. This is the first report demonstrating that in vivo supplementation of nanomolar concentrations of a prototypic nitro-fatty acid induces tissue protective effects. The in vivo administration (21 days) of nitro-oleic acid inhibited neointimal hyperplasia after wire injury of the femoral artery in a murine model. Increased heme oxygenase (HO)-1 expression accounted for much of the vascular protection because inhibition of neointimal hyperplasia following femoral artery injury was abolished in HO-1 knockout mice. Thus, electrophilic nitro-fatty acids induce salutary gene expression and cell functional responses that are manifested by a clinically significant outcome, inhibition of neointimal hyperplasia induced by arterial injury.

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