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See Latest ArticlesUrocortin 2 Inhibits Furosemide-induced Activation of Renin and Enhances Renal Function and Diuretic Responsiveness in Experimental Heart Failure
Circulation: Heart Failure, 10/02/09
Rademaker MT et al. – Ucn2 co–treatment with furosemide enhanced hemodynamic and renal function and diuretic responsiveness (without additional potassium depletion) in experimental HF. Furthermore, Ucn2 reversed furosemide–induced rises in PRA and induced greater decreases in plasma aldosterone and vasopressin. These data indicate that adjunct Ucn2 therapy with diuretics in HF is beneficial.
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